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http://www.acog.org/~/media/For%20Patients/faq072.pdf?dmc=1&ts=20140123T1626380754. In an embodiment, the 7,9-substituted tetracycline compound is 7,9-substituted tetracycline (e.g., wherein R 4 is NR 4'R 4"; R 4' and R 4" are methyl, R 5 is hydrogen and X is CR 6R 6', wherein R 6 is methyl and R 6' is hydroxy); 7,9-substituted doxycycline (e.g., wherein R 4 is NR 4'R 4"; R 4' and R 4" are methyl, R 5 is hydroxyl and X is CR 6R 6', wherein R 6 is methyl and R 6' is hydrogen); or 7, 9- substituted sancycline (wherein R 4 is NR 4'R 4"; R 4' and R 4" are methyl; R 5 is hydrogen and X is CR 6R 6' wherein R 6 and R 6' are hydrogen atoms.
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